Liver microsomal membrane fluidity and lipid characteristics in vitamin A-deficient rats.
نویسندگان
چکیده
Rat liver microsomes (microsomal fraction) were isolated from vitamin A-deficient and -sufficient rats and analysed for membrane lipid characteristics. Membrane fluidity was found to be significantly decreased in microsomes from the vitamin A-deficient rats, but not in liposomes prepared from lipid extracts. Microsomes from vitamin A-deficient animals showed a significant decrease in C18:2, omega 6 and an increase in C22:5, omega 6 fatty acids.
منابع مشابه
Microsomal lipid peroxidation and oxidative metabolism in rat liver: influence of vitamin A intake.
Introduction In several experimental animal systems, lack of vitamin A is associated with enhanced susceptibility to chemical carcinogenesis [1-3] and there are reports also of alterations in the activity of certain microsomal oxidation-reduction enzymes [4-:-6]. It seemed possible that both effects are related to loss of vitamin A protection against free radical-induced membrane-lipid peroxida...
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عنوان ژورنال:
- The Biochemical journal
دوره 245 3 شماره
صفحات -
تاریخ انتشار 1987